Research Explorer

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Project

From thiazepane curcuminoid hit structures to new anticancer lead compounds

Outputs and Outcomes

Code

01IO0620

Duration

01 October 2020 → 30 September 2024

Funding

Regional and community funding: Special Research Fund

Promotor

John Van Camp

Research disciplines

Natural sciences
- (Bio)molecular modelling and design
Medical and health sciences
- Oncology not elsewhere classified
- Compound screening

Keywords

Thiazepanes Curcumin Hit-to-lead optimization Anticancer activity

Project description

This project has the ambition to advance thiazepane-based curcuminoid hit molecules, discovered in previous research, towards new anticancer lead compounds. To that end, a thorough medicinal chemistry hit expansion and SAR evaluation study will be performed, approached from an unprecedented food science perspective, as well as elaborate biological investigations of these previously developed hits in an oncology context.

English

Dutch

English

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