Project

Role of eicosanods in T-cell and dendritic cell activation in chronic rhinosinusitis/nasal polyposis with specialattention to aspirin exacerbated respiratory disease (AERD)

Duration
01 October 2008 → 30 September 2015
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Immunology
    • Laboratory medicine
    • Otorhinolaryngology
    • Immunology
    • Laboratory medicine
    • Otorhinolaryngology
    • Speech, language and hearing sciences
    • Immunology
    • Laboratory medicine
    • Otorhinolaryngology
Keywords
aspirin dendritic cells T-cells
 
Project description

AERD constitute a severe form of airway inflammation within the group of patients with nasal polyposis and steroid-dependent asthma. We suggest that the development of the disease is linked to a disregulation of T-cell/DC function and an imbalance in the eicosanoid metabolism. The objective of the work is unravel the role of eicosanoids and aspirin desensitization on T-cel/DC differentiation/activation.