Project

Therapeutic potential of mesenchymal stromal cells

Code
bof/baf/4y/2024/01/1024
Duration
01 January 2024 → 31 December 2025
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Stem cell biology
    • Tissue engineering
  • Agricultural and food sciences
    • Veterinary physiology, pathophysiology and biochemistry
Keywords
3D cultures in vitro models mesenchymal stem cells mechanical stimulation
 
Project description
 

There is a marked disparity between the presumptive benefits of mesenchymal stromal cell (MSC) therapy and the actual observed outcome in rigorously controlled scientific studies. Therefore, more fundamental research is mandatory to provide proof of concept for current MSC-based therapies. To this end, a state-of-the-art lab was set up focusing on the isolation, characterization, differentiation and cryopreservation of MSC, isolated from different sources (bone marrow, adipose tissue, peripheral blood, umbilical cord blood and Wharton’s jelly) and in different species (horse, dog, sheep, pig and cow). The interdisciplinary research focusses both on the myogenic differentiation of MSC (with as ultimate goal the production of cultured meat) as well as their therapeutic potential to treat orthopedic injuries. By establishing representative in vitro models, the mechanism of action of MSC can be explored while a platform to screen novel therapeutics would become available. 

 

 

 

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