Project

Functional analysis of inflammasome and immune signaling in conditionally targeted NLRP2-deficient mice

Duration
01 January 2015 → 31 December 2020
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Immunology
    • Orthopaedics
    • Physiology
    • Immunology
    • Microbiology
    • Orthopaedics
    • Physiology
    • Immunology
    • Orthopaedics
    • Physiology
Keywords
immunity NOD-like receptor inflammasome
 
Project description

In this project, we will define the cellular and molecular mechanisms by which NLRP2 regulates innate and adaptive immune signaling during bacterial infection. To this end, we generated mice with a conditionally targeted deletion of NLRP2. These studies will help to uncover novel signaling pathways that can be therapeutically targeted to treat infectious and inflammatory diseases.