Project

Optimization of the antimicrobial treatment strategy in the intensive care unit patient.

Code
bof/baf/4y/2024/01/1029
Duration
01 January 2024 → 31 December 2025
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Medical intensive care
    • Surgical intensive care
    • Clinical microbiology
Keywords
intensive care Multi-drug resistance Antimicrobial Resistance Antimicrobial stewardship Antimicrobial treatment
 
Project description

Antimicrobial use in intensive care units (ICUs) is exceptionally high. Simultaneously, the global rise in multi-drug resistant organisms has driven increased reliance on last-resort antimicrobial treatments (AMT). Most current knowledge about the ecological impact of AMT comes from in-vitro studies, animal models, and small cohort research. However, the complex interplay between patient characteristics, antimicrobial exposure, and environmental factors—particularly in critically ill patients—remains poorly understood. Antimicrobial stewardship strategies often lack robust evidence on their ability to limit resistance and preserve future treatment options. Our research aims to evaluate the ecological effects of different AMT strategies, providing a scientific basis to support informed treatment decisions. A pilot project is underway, and additional funding would support personnel and laboratory materials to advance this critical work.