Project

Intracellular compartimentalisation of the signal transduction of 5-HT4-receptors in cardiac and gastro-intestinal tissue

Duration
01 January 2009 → 14 October 2014
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Cardiac and vascular medicine
    • Gastro-enterology and hepatology
    • Cardiac and vascular medicine
    • Gastro-enterology and hepatology
    • Biomarker discovery and evaluation
    • Drug discovery and development
    • Medicinal products
    • Pharmaceutics
    • Pharmacognosy and phytochemistry
    • Pharmacology
    • Pharmacotherapy
    • Toxicology and toxinology
    • Other pharmaceutical sciences
    • Cardiac and vascular medicine
    • Gastro-enterology and hepatology
Keywords
5-HT4 receptor heart compartimentalisatie colon pig human
 
Project description

The signal transduction involved in the positive inotropic and chronotropic answer to stimulation of the 5-HT4-receptors on the cardiac myocytes is investigated, in particular the intracellular compatimentalisation through phosphodiesterases and protein kinase A anchoring proteins (AKAPs). In the colon this is evaluated for the different cell types possessing 5-HT4-receptors (cholinergic neurons, nitrergic neurons, smooth muscle cells).