Code
01SC8225
Duration
01 October 2025 → 30 September 2029
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
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Natural sciences
- Virology
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Medical and health sciences
- Vaccinology
- Medicinal chemistry
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Engineering and technology
- Medical molecular engineering of nucleic acids and proteins
Keywords
Self-amplifying RNA vaccines
circular RNA vaccines
canine distemper virus
Project description
In this project we will develop novel self-amplifying (sa)RNAs and circular (circ)RNAs with optimal expression in canine. The best performing saRNA and circRNA will be used to design vaccines against canine distemper virus. The immunogenicity of the vaccines will be tested in mice and ferrets. The most efficient RNA vaccine will subsequently be evaluated in a challenge experiment in ferrets.