Code
31522308
Duration
01 January 2008 → 31 December 2010
Funding
Research Foundation - Flanders (FWO)
Promotor
Research disciplines
-
Medical and health sciences
- Immunology
- Laboratory medicine
- Palliative care and end-of-life care
- Regenerative medicine
- Other basic sciences
- Immunology
- Laboratory medicine
- Palliative care and end-of-life care
- Regenerative medicine
- Other clinical sciences
- Other health sciences
- Nursing
- Other paramedical sciences
- Immunology
- Laboratory medicine
- Palliative care and end-of-life care
- Regenerative medicine
- Other translational sciences
- Other medical and health sciences
Keywords
tumor antigen
immunotherapy
T cell
Project description
In this project we will further study and optimise the generation of mature CD3+TCRab+ (CD4+ and CD8+) T-cells from human HSC (from postnatal thymus and cord blood) using the in vitro OP9-DL1 culture system. Several methods for the generation of tumor antigen specific T-cells will be tested out. Finally, these tumor antigen specific T-cells will be introduced in a preclinical mouse model.