Bioactive thiol-ene-based polyester 3D-constructs for hard tissue engineering

15 April 2023 → 30 September 2025
Regional and community funding: Industrial Research Fund
Research disciplines
  • Natural sciences
    • Synthesis of materials
  • Engineering and technology
    • Biomaterials
    • Polymer processing
    • Tissue engineering
Non-load-bearing hard tissue engineering anti-bacterial thiol-ene photo-crosslinking cell-adhesiveness biomaterial inks light-based 3D-printing biological characterization
Project description

Bioresorbable synthetic polymers hold great potential in personalized and regenerative medicine. Within the rapidly innovating 3D printing and medical device industry, there is an unmet need for materials that combine the ideal properties for applications in hard tissue engineering and patient-specific implants: tunable degradation, cell interactivity, excellent CAD/CAM mimicry using light-based 3D printing techniques and the right mechanical properties for the engineering of hard tissues constructs and implants. UGent has generated a new and improved PCL-based polymer, which serves as a precursor for the formation of photo-polymerized networks that meet these requirements. The aim of the project is 1) to optimize  photo-crosslinkable resins (based on the UGent patented polymer technology) for use in light-based 3D printing techniques and 2) the development of a new concept in which the synthetic 3D-printed networks are adapted to become cell-interactive, through the encapsulation of chemical motives during the photo-polymerization process. Furthermore, this concept will be expanded with the incorporation of growth factors and antimicrobial chemical entities in order to serve several potential applications in the broad domain of tissue engineering and implantable medical devices.