Project

Data Independent Acquisition Mass Spectrometry to Mine Human Stem Cell Histone Epigenetics

Duration
01 October 2015 → Ongoing
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Systems biology
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
Keywords
Histones mass spectrometry epigenetics
 
Project description

Epigenetic modifications are essential in the regulation of many biological processes. The histone proteins that are intimately associated with DNA to form the chromatin are pivotal substrates herein. Here, we will apply bottom-up mass spectrometry data independent acquisition strategies to map thousands of PTM in a quantitative manner and to generate a first bird’s eye view of the so-called “histone code”.