Identification and functional characterization of novel cadherin-binding proteins via purification of tagged cadherins in transgenic Xenopus embryos

01 January 2009 → 31 December 2011
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Animal biology
    • Biochemistry and metabolism
    • Genetics
    • Systems biology
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
  • Agricultural and food sciences
    • Veterinary medicine
transgenic animals cadherins protein complexes Xenopus
Project description

The central aim of this project is the pruification of proteins associated with E- and N-cadherin. This will be done in the context of a whole organism. For this we make use of transgenic lines of Xenopus tropicalis that express modified versions of E- and N-cadherin. THese are linked to a tag that can be used for purification. Interacting proteins will be identified usin mass spec analysis.