Agriculture is plagued by an increasing frequency of floods, triggered by global climate change. Besides causing tremendous economic losses, this jeopardizes worldwide food security. The grand challenges of the 21st century, stated by the UN, include development of sustainable strategies that support crop productivity to eradicate hunger (UN-SDG2) and combat impact of global change (SDG13). Plants respond to flooding in different ways in order to promote their survival. The plant hormone ethylene plays a pivotal role therein; acting as a warning signal and triggering adaptations that facilitate survival. In addition, transport of its direct precursor ACC, a 3-membered ring amino acid, is essential for ethylene-mediated responses. Recent studies suggest that ACC itself could play a role upon stress. This opens the intriguing question of how ACC and ethylene signals control communication between organs, tissues, and cell-types to steer growth. As spatial characteristics of hormone biology are often neglected, though being a prerequisite to thoroughly understand stress responses, we plan phenotypic, molecular, and biochemical assays on a set of transgenic lines in which ethylene signaling is blocked in given cell-types. We strive to build a model for ACC and ethylene metabolism on a cell-type basis in root and shoot. Overall, this work will greatly benefit our knowledge on flooding biology, as well as future engineering approaches for the development of flood-resilient plants.