Research Explorer

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Project

Regulation of goblet cell homeostasis by the AGR2-IRE1b axis

Outputs and Outcomes

Publications

The IRE1β-mediated unfolded protein response is repressed by the chaperone AGR2 in mucin producing cells

Lisa NeidhardtEva ClootsNatalie FriemelCaroline A M WeissHeather P HardingStephen H McLaughlinSophie JanssensDavid Ron

A1 Journal Article in EMBO JOURNAL

Activation of goblet-cell stress sensor IRE1β is controlled by the mucin chaperone AGR2

Eva ClootsPhaedra GuilbertMathias ProvostLisa NeidhardtEvelien Van De VeldeFarzaneh FayazpourDelphine De SutterSavvas SavvidesSven EyckermanSophie Janssens

A1 Journal Article in EMBO JOURNAL

Canonical IRE1 function needed to sustain vigorous natural killer cell proliferation during viral infection

Jessica VettersMary van HeldenClint De NolfSofie RennenEva ClootsEvelien Van De VeldeFarzaneh FayazpourJustine Van MoorleghemManon VanheerswynghelsKarl VergoteLouis BoonEric VivierBart LambrechtSophie Janssens et al.

A1 Journal Article in ISCIENCE

IRE1 beta does not affect mucus secretion during allergic asthma development in a house dust mite murine model

Eva ClootsNincy DebeufKim DeswarteFarzaneh FayazpourManon VanheerswynghelsCaroline De WolfEvelien Van de VeldeHamida HammadBart LambrechtSven EyckermanSophie Janssens et al.

A1 Journal Article in ALLERGY

Evolution and function of the epithelial cell-specific ER stress sensor IRE1β

Eva ClootsMariska S. SimpsonClint De NolfWayne I. LencerSophie JanssensMichael J. Grey

A1 Journal Article in MUCOSAL IMMUNOLOGY