Research Explorer

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Project

Single cell analysis of inflammasome-mediated IL-1ß secretion in primary human monocytes

Outputs & Impact

Publications & research data ( 12 )

Pyrin inflammasome-driven erosive arthritis caused by unprenylated RHO GTPase signaling

Muralikrishna AkulaElisabeth GilisPieter HertensLieselotte Vande WalleMozes SzeJulie CoudenysYunus IncikOmar KhanMartin O. BergoDirk Elewaut et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

MAP kinase signaling at the crossroads of inflammasome activation

Alex VervaekeMohamed Lamkanfi

A1 Journal Article in IMMUNOLOGICAL REVIEWS

NLRP3 inflammasome activation and pyroptosis are dispensable for tau pathology

Ine PaesmansKristof Van KolenMarc VandermeerenPei-Yu ShihDirk WuytsFleur BooneSergio Garcia SanchezKarolien GrauwenFilip Van HauwermeirenNina Van Opdenbosch et al.

A1 Journal Article in FRONTIERS IN AGING NEUROSCIENCE

Oxylipins and metabolites from pyroptotic cells act as promoters of tissue repair

Parul MehrotraSophia MaschalidiLaura BoeckaertsChristian MaueröderRochelle TixeiraJonathan PinneyJavier BurgoaVladimir SukhovYunus IncikChristopher Anderson et al.

A1 Journal Article in NATURE

Novel chemotype NLRP3 inhibitors that target the CRID3-binding pocket with high potency

Lieselotte Vande WalleMadhukar SaidOonagh PaerewijckArinna BertoniMarco GattornoBruno LinclauMohamed Lamkanfi

A1 Journal Article in LIFE SCIENCE ALLIANCE

Inflammasome signaling is dispensable for ß-amyloid-induced neuropathology in preclinical models of Alzheimer's disease

Sahana SrinivasanDaliya KanchevaSofie De RenTakashi SaitoMaude JansFleur BooneCharysse VandendriesscheIne PaesmansHerve MaurinRoosmarijn Vandenbroucke et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Drugging the NLRP3 inflammasome : from signalling mechanisms to therapeutic targets

Lieselotte Vande WalleMohamed Lamkanfi

A1 Journal Article in NATURE REVIEWS DRUG DISCOVERY

The autoinflammation-associated NLRC4<SUP>V341A</SUP> mutation increases microbiota-independent IL-18 production but does not recapitulate human autoinflammatory symptoms in mice

Elien EeckhoutTomoko AsaokaHanne Van GorpDieter DemonCharlotte Girard-Guyonvarc'hVanessa AndriesLars VereeckeCem GabayMohamed LamkanfiGeert van Loo et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Protein citrullination and NET formation do not contribute to the pathology of A20/TNFAIP3 mutant mice

Karel Van DammePieter HertensArne MartensElisabeth GilisDario PriemInge BruggemanAmelie FossoulJozefien DeclercqHelena Catharine AegerterAndy Wullaert et al.

A1 Journal Article in SCIENTIFIC REPORTS

Comment on : effective ex vivo inhibition of cryopyrin-associated periodic syndrome (CAPS)-associated mutant NLRP3 inflammasome by MCC950/CRID3

Lieselotte Vande WalleMohamed Lamkanfi

A1 Journal Article in RHEUMATOLOGY

How to dodge pyroptosis : lessons from Shigella flexneri

Filip Van HauwermeirenMohamed Lamkanfi

A1 Journal Article in CELL RESEARCH

Nonredundancy of IL-1 alpha and IL-1 beta is defined by distinct regulation of tissues orchestrating resistance versus tolerance to infection

Kevin EislmayrAnnika BestehornLuisa MorelliMartina BorroniLieselotte Vande WalleMohamed LamkanfiPavel Kovarik

A1 Journal Article in SCIENCE ADVANCES

Activities ( 0 )

Results

Impact narratives ( 0 )

Patents ( 0 )