Research Explorer

Project

Retinitis pigmentosa: gene discovery and functional analysis through advanced genomics and zebrafish studies
Code
3E011511
Duration
01 October 2011 → 13 January 2018
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Laboratory medicine
    • Medical systems biology
    • Laboratory medicine
    • Medical systems biology
    • Molecular and cell biology
    • Laboratory medicine
    • Medical systems biology
    • Molecular and cell biology
Keywords
next-generation sequencing zebrafish retinitis pigmentosa gene identification
 
Project description
 

The general objective of this project is disease gene discovery in sporadic or autosomal recessive retinitis pigmentosa (RP). Specific objectives are: (1) prescreening of all known RP genes using next-generation sequencing (NGS); (2) identification of new disease genes through homozygosity mapping and NGS of candidate regions; (3) in vivo functional analysis of newly identified RP genes in zebrafish.