Ion mobility assisted Data Independent Acquisition of the histone code: opening up peptide-centric data mining.

01 October 2017 → Ongoing
Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Bio-informatics and computational biology not elsewhere classified
    • Epigenetics
    • Genetics
Histones Epigenetics Mass spectrometry
Project description

Histone proteins are intimately associated with DNA to form the chromatin. Epigenetic posttranslational modifications (PTM) on histones regulate transcription in all Eukaryotes. Here, we will apply the latest in bottom-up mass spectrometry data independent acquisition (DIA) to simultaneously map hundreds of PTM combinations in a quantitative manner and to generate a first bird’s eye view of the so-called histone code.