Research Explorer

Project

Role of Transient Receptor Potential (TRP) channels in cigarette smoke-induced pulmonary inflammation and in the pathogenesis of chronic obstructive pulmonary disease (COPD)
Code
3G089612
Duration
01 January 2012 → 31 December 2017
Funding
Research Foundation - Flanders (FWO)
Promotor
Research disciplines
  • Medical and health sciences
    • Physiology
    • Respiratory medicine
    • Physiology
    • Respiratory medicine
    • Physiology
    • Respiratory medicine
Keywords
cigarette smoke COPD TRP-channels
 
Project description
 

The role of Transient Receptor Potential (TRP) cation channels in cigarette smoke (CS)-induced inflammation and in the pathology of chronic obstructive pulmonary disease (COPD), will be investigated using human samples and a murine COPD-model. The effect of CS-exposure on the expression and functional properties of TRP channels will be assessed using wild type mice, TRP knockout mice and specific TRP-channel inhibitors.