Research Explorer

Project

The role of Ltab in the regulation of thymic emigration and peripheral homing of Vai NKT cells
Code
01P04007
Duration
01 October 2007 → 01 February 2011
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Immunology
    • Laboratory medicine
    • Orthopaedics
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other basic sciences
    • Immunology
    • Laboratory medicine
    • Orthopaedics
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other clinical sciences
    • Other health sciences
    • Nursing
    • Other paramedical sciences
    • Immunology
    • Laboratory medicine
    • Orthopaedics
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other translational sciences
    • Other medical and health sciences
Keywords
thymus NKT cells lymphotoxin emigration development
 
Project description

Research conducted by our group has demonstrated that an LTab-LTbR interaction is required fetally as well as neonatally during the development of Vai NKT cells. This process is dependent upon an LTab-LTbR interaction during the development of the thymus and is specific for the ontogeny of Vai NKT cells as the ontogeny and emigration of conventional T cells is independent of an LTab-LTbR signaling event.