Research Explorer

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Project

Targeting the mevalonate pathway to treat inflammatory diseases

Outputs and Outcomes

Publications

Myeloid A20 is critical for alternative macrophage polarization and type-2 immune-mediated helminth resistance

Ioanna PettaMarie ThorpMaarten CiersGillian BlanckeLouis BoonTim MeeseFilip Van NieuwerburghAndy WullaertRichard GrencisDirk ElewautGeert van LooLars Vereecke et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

A20 : a jack of all trades

Pieter HertensGeert van Loo

Editorial material

Myeloid OTULIN deficiency couples RIPK3-dependent cell death to Nlrp3 inflammasome activation and IL-1β secretion

Maria Giulia DoglioLien VerboomEmily Ruilova SosorangaUlrika FrisingTomoko AsaokaYannick GansemansFilip Van NieuwerburghGeert van LooAndy Wullaert

A1 Journal Article in SCIENCE IMMUNOLOGY

OTULIN protects the intestinal epithelium from apoptosis during inflammation and infection

Lien VerboomChristopher AndersonMaude JansIoanna PettaGillian BlanckeArne MartensMozes SzeTino HochepiedKodi RavichandranLars VereeckeGeert van Loo et al.

A1 Journal Article in CELL DEATH & DISEASE

Death by TNF : a road to inflammation

Geert van LooMathieu Bertrand

A1 Journal Article in NATURE REVIEWS IMMUNOLOGY