Research Explorer

Your browser does not support JavaScript or JavaScript is not enabled. Without JavaScript some functions of this webapplication may be disabled or cause error messages. To enable JavaScript, please consult the manual of your browser or contact your system administrator.

Project

Targeting the mevalonate pathway to treat inflammatory diseases

Outputs & Impact

Publications & research data ( 7 )

Pyrin inflammasome-driven erosive arthritis caused by unprenylated RHO GTPase signaling

Muralikrishna AkulaElisabeth GilisPieter HertensLieselotte Vande WalleMozes SzeJulie CoudenysYunus IncikOmar KhanMartin O. BergoDirk Elewaut et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

Colibactin-driven colon cancer requires adhesin-mediated epithelial binding

Maude JansMagdalena KolataGillian BlanckeAline D'HondtClaudia GrafMaarten CiersMozes SzeAlexandra ThiranIoanna PettaVanessa Andries et al.

A1 Journal Article in NATURE

Myeloid A20 is critical for alternative macrophage polarization and type-2 immune-mediated helminth resistance

Ioanna PettaMarie ThorpMaarten CiersGillian BlanckeLouis BoonTim MeeseFilip Van NieuwerburghAndy WullaertRichard GrencisDirk Elewaut et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

A20 : a jack of all trades

Pieter HertensGeert van Loo

Editorial material

Myeloid OTULIN deficiency couples RIPK3-dependent cell death to Nlrp3 inflammasome activation and IL-1β secretion

Maria Giulia DoglioLien VerboomEmily Ruilova SosorangaUlrika FrisingTomoko AsaokaYannick GansemansFilip Van NieuwerburghGeert van LooAndy Wullaert

A1 Journal Article in SCIENCE IMMUNOLOGY

OTULIN protects the intestinal epithelium from apoptosis during inflammation and infection

Lien VerboomChristopher AndersonMaude JansIoanna PettaGillian BlanckeArne MartensMozes SzeTino HochepiedKodi RavichandranLars Vereecke et al.

A1 Journal Article in CELL DEATH & DISEASE

Death by TNF : a road to inflammation

Geert van LooMathieu Bertrand

A1 Journal Article in NATURE REVIEWS IMMUNOLOGY

Activities ( 0 )

Results

Impact narratives ( 0 )

Patents ( 0 )