Identification, lead optimization and validation of necroptosis inhibitors

01 January 2013 → 31 December 2018
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Analysis
    • Organic chemistry
    • Systems biology
RIP kinases TNF necroptosis
Project description

Current findings suggest that necroptotic cell death may be involved in multiple inflammatory diseases. Interfering in the cellular pathways leading to necrosis might thus be a valuable target for therapeutic intervention in these diseases, as an alternative for the current anti-TNF therapies, which have serious drawbacks. Therefore, this project will focus on the identification and validation of necroptosis inhibitors.