Project

Spatio-temporal aspects and function of MLKL at plasma membrane during necroptosis.

Duration
01 October 2015 → 30 September 2019
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Systems biology
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
Keywords
relocalization MLKL necroptosis plasma membrane
 
Project description

MLKL was recently discovered as crucial executioner in necroptosis. Upon RIPK3-mediated phosphorylation, MLKL relocalizes at the plasma membrane. While MLKL function is still controverted, recent data advocate for a pore-forming capacity of MLKL. In this project, we will visualize the molecular events leading to MLKL plasma membrane relocalization and determine MLKL dynamics and function at the plasma membrane.