Project

Spatio-temporal aspects and function of MLKL at plasma membrane during necroptosis.

Code

3F003115

Duration

01 October 2015 → 30 September 2019

Funding

Research Foundation - Flanders (FWO)

Promotor

Peter Vandenabeele

Fellow

Benjamin Cappe

Research disciplines

Natural sciences
- Biochemistry and metabolism
- Systems biology
Medical and health sciences
- Medical biochemistry and metabolism
- Medical biochemistry and metabolism
- Medical biochemistry and metabolism

Keywords

relocalization MLKL necroptosis plasma membrane

Project description

MLKL was recently discovered as crucial executioner in necroptosis. Upon RIPK3-mediated phosphorylation, MLKL relocalizes at the plasma membrane. While MLKL function is still controverted, recent data advocate for a pore-forming capacity of MLKL. In this project, we will visualize the molecular events leading to MLKL plasma membrane relocalization and determine MLKL dynamics and function at the plasma membrane.