UGent Burkholderia collection as a source of unique antimicrobial molecules for treatment of infections with multi-resistant bacteria

01 January 2016 → 31 December 2016
Regional and community funding: Industrial Research Fund
Research disciplines
  • Medical and health sciences
    • Biomarker discovery and evaluation
    • Drug discovery and development
    • Medicinal products
    • Pharmaceutics
    • Pharmacognosy and phytochemistry
    • Pharmacology
    • Pharmacotherapy
    • Toxicology and toxinology
    • Other pharmaceutical sciences
antimicrobial molecules
Project description

The LM-UGent research group has built up a unique bacteria collection over the past 40 years. This collection includes more than 25,000 publicly available strains (BCCM / LMG Bacteria collection) isolated from humans, animals and nature worldwide. In addition, there is also a closed research collection with more than 70,000 isolates. Specific parts of this collection have become global reference collections. This collection has never been approached as a source of innovative natural products valuable for economic and social valorization. The troubling issue of antibiotic resistance gave rise to the initiative to screen this collection for unique substances that can be used as a basis for drug discovery. Within the larger LM-UGent collection, the Burkholderia collection was identified as the most direct opportunity.