Project

Role of caspase-11 in inflammasome and innate immune signaling

Duration
01 October 2010 → 30 September 2017
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Immunology
    • Immunology
    • Microbiology
    • Immunology
Keywords
caspase-11 inflammasome caspase-1
 
Project description

The innate immune system recognizes infections through receptors that detect conserved microbial components. Ligand-mediated activation of these receptors induces caspase-1 activation and caspase-1-mediated maturation and secretion of the inflammatory cytokines IL1β and IL18. The aim of this project is to study the role of the caspase-1 homolog, the inflammatory caspase-11, in caspase-1 inflammasome activation and secretion of inflammatory cytokines.