Research Explorer

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Project

Genetic dissection of the immune pathways that cause Aicardi-Goutières Syndrome.

Outputs and Outcomes

Publications

Novel insights into double-stranded RNA-mediated immunopathology

Richard de ReuverJonathan Maelfait

A1 Journal Article in NATURE REVIEWS IMMUNOLOGY

The Z-nucleic acid sensor ZBP1 in health and disease

Jonathan MaelfaitJan Rehwinkel

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Tyramide signal amplification for the immunofluorescent staining of ZBP1-dependent phosphorylation of RIPK3 and MLKL after HSV-1 infection in human cells

Josephine NemegeerKelly LemeirePeter VandenabeeleJonathan Maelfait

A1 Journal Article in JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation

Richard de ReuverSimon VerdonckEvelien DierickJosephine NemegeerEline HessmannSadeem AhmadMaude JansGillian BlanckeFilip Van NieuwerburghAlexander BotzkiLars VereeckeGeert van LooWim DeclercqSun HurPeter VandenabeeleJonathan Maelfait et al.

A1 Journal Article in NATURE