Project

Nucleophilic Nanoparticles for optimal delivery of plasmid DNA in dividing cells

Code

3E012607

Duration

01 October 2007 → 30 September 2014

Funding

Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)

Promotor

Jo Demeester

Fellow

Katrien Remaut

Research disciplines

Medical and health sciences
- Biomarker discovery and evaluation
- Drug discovery and development
- Medicinal products
- Pharmaceutics
- Pharmacognosy and phytochemistry
- Pharmacology
- Pharmacotherapy
- Toxicology and toxinology
- Other pharmaceutical sciences
Engineering and technology
- Chemical product design and formulation
- Process engineering
- Polymeric materials
- Biomaterials engineering

Keywords

plasmid DNA non-viral gene therapy nuclear membrane

Project description

Plasmid DNA needs to reach the cell nucleus to be biologically active. We aim to explore new strategies to target naked DNA or DNA nanoparticles to the cell nuclei of daughter cells during the cell division of the mother cell, since during cell division the intracellular barrier of the nuclear membrane is temporarily broken down.