Research Explorer

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Project

Synergistic engineering of anti-tumor immunity by synthethic biomaterials

Outputs & Impact

Publications & research data ( 11 )

Thioamides adjacent to the ionizable amine headgroup in ionizable lipids reduce the pKa of lipid nanoparticles and enhance mRNA transfection efficiency in vitro and in vivo

Yong ChenEmily De LombaerdeAimee-Rose Bugler-LambZifu ZhongMartijn SchuijsClaudia Mariela Brenis GómezJamie De BaereMark GontsarikHeleen LauwersKim Deswarte et al.

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

HER2 nanobody-poly(rhamnose) conjugates efficiently recruit anti-rhamnose antibodies from serum to the surface of HER2-expressing cells

Weiwei MuYong ChenZifu ZhongBenoit LouageHeleen LauwersNick DevoogdtJurgen HaustraeteBruno De Geest

A1 Journal Article in CHEMISTRY OF MATERIALS

Lipid nanoparticle composition for adjuvant formulation modulates disease after influenza virus infection in quadrivalent influenza vaccine vaccinated mice

Sonia JangraAlexander LamootGagandeep SinghGabriel LaghlaliYong ChenTingting YeAdolfo García-SastreBruno De GeestMichael Schotsaert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Combinatorial screening of biscarbamate ionizable lipids identifies a low reactogenicity lipid for lipid nanoparticle mRNA delivery

Emily De LombaerdeYong ChenTingting YeJulie DeckersGiulia MencarelliKim DeswarteHeleen LauwersRuben De CoenSabah KasmiSanne Bevers et al.

A1 Journal Article in ADVANCED FUNCTIONAL MATERIALS

Lipid nanoparticle encapsulation empowers poly(I:C) to activate cytoplasmic RLRs and thereby increases its adjuvanticity

Alexander LamootSonia JangraGabriel LaghlaliPrajakta WarangLauren A. ChangSeok‐Chan ParkGagandeep SinghKim DeswarteZifu ZhongBenoit Louage et al.

A1 Journal Article in SMALL

Successful batch and continuous lyophilization of mRNA LNP formulations depend on cryoprotectants and ionizable lipids

Alexander LamootJoris LammensEmily De LombaerdeZifu ZhongMark GontsarikYong ChenThomas De BeerBruno De Geest

A1 Journal Article in BIOMATERIALS SCIENCE

Lipid nanoparticle delivery alters the adjuvanticity of the TLR9 agonist CpG by innate immune activation in lymphoid tissue

Zifu ZhongYong ChenKim DeswarteHeleen LauwersEmily De LombaerdeXiaole CuiSimon Van HerckTingting YeMark GontsarikStefan Lienenklaus et al.

A1 Journal Article in ADVANCED HEALTHCARE MATERIALS

Towards a rational design of antibody‐recruiting molecules through a computational microscopy view of their interactions with the target antibody

Annemiek UvynCorentin TonneauxMathieu FossépréAude Ouvrier‐BuffetBruno De GeestMathieu Surin

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

Hapten/myristoyl functionalized poly(propyleneimine) dendrimers as potent cell surface recruiters of antibodies for mediating innate immune killing

Annemiek UvynMarle Elisabeth Jacqueline VleugelsBas de WaalAhmed Emad Ibrahim HamoudaShikha DhimanBenoit LouageLorenzo AlbertazziDamya LaouiE. W. MeijerBruno De Geest

A1 Journal Article in ADVANCED MATERIALS

LXR signaling controls homeostatic dendritic cell maturation

Victor BosteelsSandra MaréchalClint De NolfSofie RennenJonathan MaelfaitSimon TavernierJessica VettersEvelien Van De VeldeFarzaneh FayazpourKim Deswarte et al.

A1 Journal Article in SCIENCE IMMUNOLOGY

Lipid nature and alkyl length influence lymph node accumulation of lipid-polyethylene glycol amphiphiles

Jana De VriezeAntonio Pires da Silva BaptistaLutz NuhnSimon Van HerckKim DeswarteHaijun YuBart LambrechtBruno De Geest

A1 Journal Article in ADVANCED THERAPEUTICS

Activities ( 0 )

Results

Impact narratives ( 0 )

Patents ( 0 )