Code
01D22713
Duration
01 October 2013 → 30 September 2017
Funding
Regional and community funding: Special Research Fund
Promotor
Fellow
Research disciplines
-
Natural sciences
- Other biological sciences
-
Medical and health sciences
- Physiology
- Physiology
- Physiology
Keywords
cell death
gap junctions
intercellular communication
connexins
inositol trisphosphate
calcium
Project description
Diffusion of the physiological molecule inositol trisphosphate (IP3) via gap junctions is crucial to evoke bystander apoptosis. We here aim to explore conditions that are necessary to convert IP3 into a cell death molecule. Secondly, we will investigate bystander cell death in other cell death modalities as well as in a clinically relevant model of ischemia-reperfusion injury to cardiomyocytes.