Acronym
Bio-POMs
Code
01N03217
Duration
01 January 2017 → 31 October 2021
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
-
Natural sciences
- Bioinorganic chemistry
Keywords
Polyoxometalates
Bio-inorganic chemistry
crystallography
Project description
Polyoxometalates (POMs) are metal-oxygen anionic clusters, which show huge potential for biomedical applications. The major drawback in using POMs in biomedicine is their inherent low cell delivery, mostly because of their negative charge, hampering translocation through hydrophobic membranes. Here, we propose to develop bio-conjugated POMs, asymmetrically functionalized with both cell-penetrating (CPPs) and homing peptides, for enhanced bioavailability and specificity.