Project

Bio-POMs: Bio-conjugation of PolyOxoMetalates for Life Science Applications

Acronym
Bio-POMs
Duration
01 January 2017 → 31 October 2021
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Bioinorganic chemistry
Keywords
Polyoxometalates Bio-inorganic chemistry crystallography
 
Project description

Polyoxometalates (POMs) are metal-oxygen anionic clusters, which show huge potential for biomedical applications. The major drawback in using POMs in biomedicine is their inherent low cell delivery, mostly because of their negative charge, hampering translocation through hydrophobic membranes. Here, we propose to develop bio-conjugated POMs, asymmetrically functionalized with both cell-penetrating (CPPs) and homing peptides, for enhanced bioavailability and specificity.