Project

Study of the transcriptional cross-talk between PPARalfa and ERRalfa

Code
01J01313
Duration
01 March 2013 β†’ 31 December 2017
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
Keywords
molecular endocrinology gene transcription nuclear receptors
 
Project description

We found a direct link between a key regulator of oxidative metabolism, ERRalfa, and a nuclear receptor that mediates not only metabolic but also anti-inflammatory actions (PPARalfa). The main objectives are to understand the function and mechanism of this interaction, to identify modulators hereof and to investigate the interaction profile in a relevant animal disease model or human heart tissue.