Research Explorer

Project

Mode of action of house dust mite specific immunotherapy.
Code
3F001813
Duration
01 October 2013 → 30 September 2017
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Immunology
    • Laboratory medicine
    • Otorhinolaryngology
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Respiratory medicine
    • Other basic sciences
    • Immunology
    • Laboratory medicine
    • Otorhinolaryngology
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Respiratory medicine
    • Other clinical sciences
    • Other health sciences
    • Nursing
    • Speech, language and hearing sciences
    • Other paramedical sciences
    • Immunology
    • Laboratory medicine
    • Otorhinolaryngology
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Respiratory medicine
    • Other translational sciences
    • Other medical and health sciences
Keywords
Specific immunotherapy Allergic airway inflammation Humanized SCID mouse model House dust mite
 
Project description
 

The proposed project aims to elucidate the mode of action of house dust mite specific immunotherapy. We will address this question in 2 different ways:

- Ex vivo: in peripheral blood and at local tissue level of patients undergoing HDM SIT.

- In vivo: in severe combined immunodeficiency mice reconstituted with peripheral blood mononuclear cells of patients undergoing HDM SIT.