Code
3E000910
Duration
01 October 2010 → 30 September 2013
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Promotor
Fellow
Research disciplines
-
Natural sciences
- Biochemistry and metabolism
- Systems biology
-
Medical and health sciences
- Medical biochemistry and metabolism
- Medical biochemistry and metabolism
- Medical biochemistry and metabolism
Keywords
proteomics
antigen presentation
cathepsin
Project description
Positional proteomics to isolate N- and C-terminal peptides will be used for detailedanalyses of substrates and functions of cathepsins. Substrate catalogues of recombinantcathepsins will be generated, substrates cleaved during cell death in a mouse cellularmodel system will be mapped and the individual roles of cathepsins D and E in MHCclass II antigen presentation will be established.