The role of cathepsins in apoptosis and antigen presentation studied by positional proteomics

01 October 2010 → 30 September 2013
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Systems biology
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
proteomics antigen presentation cathepsin
Project description

Positional proteomics to isolate N- and C-terminal peptides will be used for detailedanalyses of substrates and functions of cathepsins. Substrate catalogues of recombinantcathepsins will be generated, substrates cleaved during cell death in a mouse cellularmodel system will be mapped and the individual roles of cathepsins D and E in MHCclass II antigen presentation will be established.