Project

search for new and analysis of known HIV restriction factors

Duration
01 January 2011 → 16 September 2012
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Systems biology
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
Keywords
MAPPIT HIV-1 protein interactions
 
Project description

This project uses MAPPIT (Mammalian Protein-Protein Interaction Trap)to study known interactions between HIV-1 and host proteins and identifies new interactions between the two. We use a MAPPIT-based mutagenesis approach and a newly developed MAPPIT-based screening strategy to map the interaction domain for a number of protein interactions including Apobec3G-Vif and Apobec3G-gag. Array MAPPIT allows us to screen for new protein interactions.