Project

Unraveling genetic mechanisms in early onset breast cancer

Code

365R4511

Duration

01 October 2011 → 30 September 2012

Funding

Funding by bilateral agreement (private and foundations)

Promotor

Kathleen Claes

Research disciplines

Natural sciences
- Genetics
- Systems biology
Medical and health sciences
- Laboratory medicine
- Medical systems biology
- Molecular and cell biology
- Morphological sciences
- Oncology
- Laboratory medicine
- Medical systems biology
- Molecular and cell biology
- Morphological sciences
- Oncology
- Laboratory medicine
- Medical systems biology
- Molecular and cell biology
- Morphological sciences
- Oncology

Keywords

gene expression profiling inherited breast cancer miRNA profiling whole exome sequencing

Project description

Known genes only account for 28% of the heritability of breast cancer (BC). The “missing heritability” is thought to be due to individually rare, highly penetrant variants. Whole exome sequencing in constitutional and tumor DNA from patients with early onset BC is applied to identify novel BC genes. Furthermore, genome-wide miRNA and mRNA expression profiles of the tumors will aid unraveling new signaling pathways.