Code
365R4511
Duration
01 October 2011 → 30 September 2012
Funding
Funding by bilateral agreement (private and foundations)
Promotor
Research disciplines
-
Natural sciences
- Genetics
- Systems biology
-
Medical and health sciences
- Laboratory medicine
- Medical systems biology
- Molecular and cell biology
- Morphological sciences
- Oncology
- Laboratory medicine
- Medical systems biology
- Molecular and cell biology
- Morphological sciences
- Oncology
- Laboratory medicine
- Medical systems biology
- Molecular and cell biology
- Morphological sciences
- Oncology
Keywords
gene expression profiling
inherited breast cancer
miRNA profiling
whole exome sequencing
Project description
Known genes only account for 28% of the heritability of breast cancer (BC). The “missing heritability” is thought to be due to individually rare, highly penetrant variants. Whole exome sequencing in constitutional and tumor DNA from patients with early onset BC is applied to identify novel BC genes. Furthermore, genome-wide miRNA and mRNA expression profiles of the tumors will aid unraveling new signaling pathways.