Project

Novel glycoproteomics methodology for discovering tumor-specific cell surface glycopeptide epitopes.

Code

3F016717

Duration

01 October 2017 → 30 September 2021

Funding

Research Foundation - Flanders (FWO)

Promotor

Nico Callewaert

Fellow

Wannes Weyts

Research disciplines

Natural sciences
- Biochemistry and metabolism not elsewhere classified
- Proteomics
Medical and health sciences
- Cancer diagnosis

Keywords

immunotherapy target identification glycoproteomics cancer

Project description

Finding new cancer-specific glycopeptide epitopes through the development of an entirely novel glycoproteomics methodology, fully focused on the (Sia-)Tn cancer glycotype that is almost universally overproduced in (adeno)carcinomas. This is essential to bring the enormous potential of the new, potentially curative modalities of cancer immunotherapy to the vast majority of cancer patients with solid tumors that derive from epithelial cells.