Project

The Flemish exposome project: towards a comprehensive understanding of the life-course impact of dietary and environmental exposure on chronic low-grade gut inflammation (FLEXiGUT)

Acronym
FLEXiGUT
Code
01IB1320
Duration
01 January 2021 → 31 December 2024
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Other environmental sciences not elsewhere classified
  • Medical and health sciences
    • Emergency medicine anaesthesiology
    • Bioinformatics data integration and network biology
    • Medical metabolomics
    • Microbiome
Keywords
chronic exposure human biomonitoring Exposome microbiome metabolomics
 
Project description

The human exposome covers the totality of non-genetic exposures from conception throughout the life course. The Flemish exposome project, FLEXiGUT, combines the unique and complementary expertise in Flanders on dietary- and environment-related human biomarkers and biomonitoring, metabolomics, microbiome research and epidemiology to investigate the complex human exposome. This first large-scale Flemish Exposome study, will make use of biomonitoring and -omics based technologies on the available biological matrices of the Flemish Environage Birth and the Flemish Gut Microbiome cohorts. Associations between the acquired exposome metadata and chronic low-grade gut inflammation parameters and related diseases will be analysed using an integrated -omics approach. Our pioneering results will be validated through extension towards other international cohorts.