Interfering with QS is regarded as a promising approach to treat biofilm-related chronically infected wounds. The aim of this proposal is to explore the effect of QQ agents on the susceptibility of wound biofilms to conventional antibiotics and disinfectants based on the development of single- and poly-microbial biofilm wound model systems, and further to develop novel pharmaceutical formulations and combine the QSI and QQ compounds with maggot debridement therapy. On the basis of our previous work and cooperation in various areas, this proposal tends to be practical and meaningful to promote the application of interfering with QS in chronically infected wound treatment.