Project

The scaffolding actin nucleator tes: identification of domain specific interaction partners and its function in cell migration ands tumor cell invasion

Duration
01 October 2012 → 30 September 2016
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Systems biology
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
Keywords
tumor supressor actin cytoskeleton dynamics cell migration
 
Project description

Tes, a potential tumor suppressor, controls actin cytoskeleton assembly at cellular adhesions. We will study structure-function relationships of Tes variants lacking specific domains. By combining proteomics with live cell imaging, we will determine how Tes and two identified partners regulate actin dynamics and cell migration. This will generate information on functions and mechanisms of Tes in cell migration and invasion.