Project

Protein Modifications Associated with Oxidative and Nitrative Stress: a Gel-free Proteome Analysis

Duration
01 January 2007 → 30 December 2012
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Systems biology
  • Medical and health sciences
    • Endocrinology and metabolic diseases
    • Medical biochemistry and metabolism
    • Endocrinology and metabolic diseases
    • Medical biochemistry and metabolism
    • Endocrinology and metabolic diseases
    • Medical biochemistry and metabolism
Keywords
post-translational modifications peptides signaling proteomics
 
Project description

Increased concentrations of reacive oxygen species can induce various modifications in cellular proteins. Some are oxydations, while others are due to reactive NO-derivatives. This can lead to functional changes and often acts as signalling triggers. Using a novel gel-free proteomics approach, we will identify the protein targets and locate the sites of modification of these oxidation-related events.