Research Explorer

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Project

T cell receptor signaling pathways in autoimmune disease

Outputs and Outcomes

Code

01D02412

Duration

01 October 2012 → 30 September 2016

Funding

Regional and community funding: Special Research Fund

Promotor

Dirk Elewaut

Fellow

Elisabeth Gilis

Research disciplines

Medical and health sciences
- Immunology
- Immunology
- Immunology

Keywords

autoimmunity T cells lymphocytes

Project description

CYLD is a de-ubiquitinating enzyme that is constitutively expressed in almost all cell types. Although the impact of CYLD cleavage on lymphocyte signaling was clearly demonstrated in vitro, we do not know the impact CYLD cleavage has on lymphocyte function in vivo and its potential contribution to inflammatory and autoimmune disorders such as diabetes, arthritis and chronic bowel inflammation.

English

Dutch

English

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