Research Explorer

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Project

Barriers and carriers for non-viral delivery of mRNA to induce transient protein expression in the retina: the hurdles of the inner limiting membrane and innate immunity versus the potential of mRNA self-amplification.

Outputs & Impact

Publications & research data ( 3 )

Less is more : self-amplifying mRNA becomes self-killing upon dose escalation in immune-competent retinal cells

Helena VanlucheneOriane GillonKaren PeynshaertStefaan De SmedtNiek SandersKoen RaemdonckKatrien Remaut

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

ICG-mediated photodisruption of the inner limiting membrane enhances retinal drug delivery

Karen PeynshaertHelena VanlucheneKaat De ClerckAn-Katrien MinnaertMorgane VerhoevenNoémie GouspillouNezahat BostanToshio HisatomiGeraldine AccouFélix Sauvage et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Strategies for controlling the innate immune activity of conventional and self-amplifying mRNA therapeutics : getting the message across

An-Katrien MinnaertHelena VanlucheneRein VerbekeIne LentackerStefaan De SmedtKoen RaemdonckNiek SandersKatrien Remaut

A1 Journal Article in ADVANCED DRUG DELIVERY REVIEWS

Activities ( 0 )

Results

Impact narratives ( 0 )

Patents ( 0 )