Can a combination of isotopic analysis of Fe, Cu and Zn using multi-collector inductively coupled plasma - mass spectrometry and chemometric analysis be used for diagnosis of metal-related diseases?

01 October 2012 → 01 October 2014
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Instrumental methods
    • Inorganic elements and compounds
  • Medical and health sciences
    • General diagnostics
isotopic analysis multi-collector ICP-mass spectrometry Fe Cu Zn blood medical diagnosis
Project description

Isotopic analysis of the essential transition metals Fe, Cu and Zn in human blood via multi-collector ICP-MS after their chemical isolation. Characterization of the spread in the isotope ratios of Fe, Cu and Zn in the reference population and identification of the governing factors. Comparison of the isotopic composition of Fe, Cu and Zn in blood from the reference population to the corresponding values in patient populations. Evaluation of the capabilities of this type of isotopic analysis as a diagnostic tool.