Research Explorer

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Project

Further development of mRNA Galsomes as nanovaccines for cancer immunotherapy: combination with checkpoint inhibition and translation to the clinic.

Outputs and Outcomes

Publications

Alpha-galactosylceramide improves the potency of mRNA LNP vaccines against cancer and intracellular bacteria

Sofie MeulewaeterIlke AernoutJoke DeprezYanou EngelenMargo De VelderLorenzo FranceschiniKarine BreckpotSerge Van CalenberghCaroline AsselmanKatie BoucherFrancis ImpensStefaan De SmedtRein VerbekeIne Lentacker et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Considerations on the design of lipid-based mRNA vaccines against cancer

Sofie MeulewaeterYao ZhangAbishek WadhwaKevin FoxIne LentackerKenneth W. HarderPieter R. CullisStefaan De SmedtMiffy H.Y. ChengRein Verbeke

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

Nanobody-mediated SPECT/CT imaging reveals the spatiotemporal expression of programmed death-ligand 1 in response to a CD8+ T cell and iNKT cell activating mRNA vaccine

Thomas ErtveldtSofie MeulewaeterYannick De VlaeminckOscar OlarteKatrijn BroosSerge Van CalenberghStephanie BourgeoisJoke DeprezYves HeremansCleo GoyvaertsWillem StaelsStefaan De SmedtHeleen DewitteNick DevoogdtMarleen KeyaertsRein VerbekeKurt BarbéIne LentackerKarine Breckpot et al.

A1 Journal Article in THERANOSTICS

Transport by circulating myeloid cells drives liposomal accumulation in inflamed synovium

Joke DeprezRein VerbekeSofie MeulewaeterIlke AernoutHeleen DewitteTine DecruyJulie CoudenysJulie Van DuyseGert Van IsterdaelDan PeerRoy van der MeelStefaan De SmedtPeggy JacquesDirk ElewautIne Lentacker et al.

A1 Journal Article in NATURE NANOTECHNOLOGY

Continuous freeze-drying of messenger RNA lipid nanoparticles enables storage at higher temperatures

Sofie MeulewaeterGust NuyttenMiffy H.Y. ChengStefaan De SmedtPieter R. CullisThomas De BeerIne LentackerRein Verbeke

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE