Research Explorer

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Project

Characterizing the in vivo importance of OTULIN in liver through mouse gene targeting studies

Outputs and Outcomes

Publications

Myeloid OTULIN deficiency couples RIPK3-dependent cell death to Nlrp3 inflammasome activation and IL-1β secretion

Maria Giulia DoglioLien VerboomEmily Ruilova SosorangaUlrika FrisingTomoko AsaokaYannick GansemansFilip Van NieuwerburghGeert van LooAndy Wullaert

A1 Journal Article in SCIENCE IMMUNOLOGY

Unravelling the role of OTULIN in liver and intestinal pathology

Lien VerboomGeert van Loo

OTULIN protects the intestinal epithelium from apoptosis during inflammation and infection

Lien VerboomChristopher AndersonMaude JansIoanna PettaGillian BlanckeArne MartensMozes SzeTino HochepiedKodi RavichandranLars VereeckeGeert van Loo et al.

A1 Journal Article in CELL DEATH & DISEASE

OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity

Esther HosteKim LecomteKarl AnnusverNiels VandammeJana RoelsSophia MaschalidiLien VerboomHanna-Kaisa VikkulaMozes SzeLisette Van HoveKevin VerstaenArne MartensTino HochepiedYvan SaeysKodi RavichandranMaria KasperGeert van Loo et al.

A1 Journal Article in NATURE COMMUNICATIONS