Research Explorer

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Project

Development and validation of a juvenile porcine model to study antibiotic tissue pharmacokinetics in pediatric sepsis.

Outputs and Outcomes

Publications

Studying antibiotic tissue distribution using microdialysis : from piglets to critically ill children

Eline HermansPieter De CockMathias DevreesePeter De Paepe

Have we neglected to study target-site drug exposure in children? A systematic review of the literature

Eline HermansJozefien MeersschautIsis Van herteryckMathias DevreeseJohan Vande WallePeter De PaepePieter De Cock

A1 Journal Article in CLINICAL PHARMACOKINETICS

Microdialysis as a safe and feasible method to study target-site piperacillin-tazobactam disposition in septic piglets and children

Eline HermansMathias DevreeseMarkus ZeitlingerEvelyn DhontNick VerougstraeteRoos ColmanJohan Vande WallePeter De PaepePieter De Cock

A1 Journal Article in INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Tissue penetration of piperacillin-tazobactam in critically ill children : a microdialysis study

Eline HermansEvelyn DhontMathias DevreeseJohan Vande WallePeter De PaepePieter De Cock

Antibiotic tissue penetration in the septic piglet versus the child : lessons learnt from microdialysis

Eline HermansPieter De CockPeter De PaepeJohan Vande WalleMathias Devreese

The translation from in vitro experiments to in vivo microdialysis trials : a case study of piperacillin-tazobactam

Eline HermansMarkus ZeitlingerEvelyn DhontPeter De PaepeJohan Vande WalleMathias DevreesePieter De Cock

A piglet model of pediatric sepsis to investigate tissue penetration of antibiotics in children : a microdialysis study on piperacillin-tazobactam

Eline HermansPeter De PaepeJohan Vande WallePieter De CockMathias Devreese

The influence of sepsis on the tissue penetration of piperacillin-tazobactam in children : a microdialysis study in the juvenile pig

Eline HermansFreya MeganckPeter De PaepeJohan Vande WallePieter De CockMathias Devreese