Selection of bio-active quinoïds and analysis of a combined chemotherapy and immunoprofylaxis for the control of tuberculosis

01 January 2010 → 31 December 2015
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Organic chemistry
    • Other chemical sciences
  • Medical and health sciences
    • Laboratory medicine
    • Medical systems biology
    • Laboratory medicine
    • Medical systems biology
    • Medicinal chemistry
    • Laboratory medicine
    • Medical systems biology
  • Agricultural and food sciences
    • Agricultural plant production
antibiotics octahydrobenzophenanthridinediones 2-azaanthraquinones benzophenantridinediones
Project description

Quinones are natural products that display a variety of biological activities, amongst which antibiotic and antitumor activity, which makes them valuable for the development of new drugs. Tuberculosis is a serious infectious disease and the rise of multiresistant Mycobacteria necessitates continued research to new active compounds. In this respect, the current research proposal aims at the synthesis and bio-testing against various Mycobacteria of new 2-aza-anthraquinones, benzophenanthridinediones and octahydrobenzophenanthridinediones.