Code
3G002010
Duration
01 January 2010 → 31 December 2015
Funding
Research Foundation - Flanders (FWO)
Promotor
Research disciplines
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Natural sciences
- Organic chemistry
- Other chemical sciences
-
Medical and health sciences
- Laboratory medicine
- Medical systems biology
- Laboratory medicine
- Medical systems biology
- Medicinal chemistry
- Laboratory medicine
- Medical systems biology
-
Agricultural and food sciences
- Agricultural plant production
Keywords
antibiotics
octahydrobenzophenanthridinediones
2-azaanthraquinones
benzophenantridinediones
Project description
Quinones are natural products that display a variety of biological activities, amongst which antibiotic and antitumor activity, which makes them valuable for the development of new drugs. Tuberculosis is a serious infectious disease and the rise of multiresistant Mycobacteria necessitates continued research to new active compounds. In this respect, the current research proposal aims at the synthesis and bio-testing against various Mycobacteria of new 2-aza-anthraquinones, benzophenanthridinediones and octahydrobenzophenanthridinediones.