Project

QSAR driven design, synthesis and evaluation of anti-invasive chalcones and related heterocyclic compounds

Duration
01 October 2007 → 01 October 2008
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Organic chemistry
  • Medical and health sciences
    • Laboratory medicine
    • Medical systems biology
    • Morphological sciences
    • Oncology
    • Laboratory medicine
    • Medical systems biology
    • Morphological sciences
    • Oncology
    • Medicinal chemistry
    • Laboratory medicine
    • Medical systems biology
    • Morphological sciences
    • Oncology
Keywords
anti-invasive cancer research chalcones
 
Project description

The project aims at a focussed synthesis of functionalised chalcones ans anti-invasive compounds against breast cancer. The activity of a wide variety of functionalised chalcones will be predicted first by a developed neural computer network and the most promising compounds will then be synthesized and tested in the chick heart fragment test. The obtained results will serve as feedback in order to optimize the CODESSA programme.