About 20 years ago, a novel cell type has been discovered with unique morphology and functions, present in connective tissue of many organs of different animal species. Initially, this cell type was called Interstitial Cajal-like Cell, but in 2010 the name telocyte (TC) was proposed. The TC has a small oval-shaped cell body, with a small amount of cytoplasm rich in mitochondria, a small Golgi-complex, rough and smooth endoplasmic reticulum, and cytoskeletal elements. TCs have a variable number of long cellular extensions, called telopodes (Tps), that are made by an alternation of podoms (dilated portions containing mitochondria and endoplasmic reticulum) and podomers (thin segments). These Tps form a three-dimensional network that may function as a scaffold to define the correct organization of tissues and organs. Electron microscopy is commonly considered the gold standard method to identify TCs. However, to this day, the existence of these TCs is still controversial.