Research Explorer

Project

Induction of IgA2 class switching in human Ige+B cells as theraphy for allergic disease
Code
3E007509
Duration
01 October 2009 → 13 February 2016
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Genetics
    • Systems biology
  • Medical and health sciences
    • Molecular and cell biology
    • Molecular and cell biology
 
Project description
 

Abstract (max. 60 woorden): IgE plays a central role in allergy by activating mast cells and facilitating allergen presentation to Th2 lympghocytes. Accumulating evidence suggests that IgA plays a protective role in allergy by antagonizing the effects of IgE. Therefore using three proven IgA promoting regimens: IL-21+TGFB1, cholera toxin B (CTB) and Lactococci engineerd to express allergen and CTB