Project

Use of anatomical pathology studies and real-life data to improve care for patients with rare bone and soft tissue tumors

Code
bof/baf/4y/2024/01/553
Duration
01 January 2024 → 31 December 2025
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Molecular diagnostics
Keywords
molecular genetics sarcoma histology benchmarking sample collection pathology care improvement real-life data
 
Project description

The purpose of our project is the analysis and improvement of current care (diagnosis, treatment and follow-up) for patients with a bone or soft tissue tumor. 

Anatomopathological studies (histomorphology, immunohistochemical and molecular genetic data) and real-life data (clinical presentation and clinical follow-up; medical imaging) of patients who were discussed, examined and treated by our multidisciplinary tumor working group bone and soft tissue tumors UZ Ghent in the period 2000 – 2024 will be analyzed in detail: which (clinical, histopathological, radiological) characteristics predict the risk of local recurrence (e.g. atypical lipomatous tumors/liposarcomas, giant cell tumors, solitary fibrous tumors) and which characteristics predict a good chance of survival (response to therapy) (e.g. osteosarcomas, Ewing sarcomas). For each patient, we will provide a coupling with sample collection for scientific projects, as well as the prospective biobank collection. This will allow us to test traceability of samples and conduct a planned translational scientific project.


A benchmarking exercise with the Karolinska institute will also be set up using existing indicators.